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Hyperhomocysteinemia is probably an independent risk factor for stroke, with a prevalence of about 20%in all patients with a history of stroke; however,additional factors(eg,hypertension,hyperuricemia)may have an enhancing effect.There are significant differences in stroke patterns between patients with and without hyperhomocysteinemia,with a higher rate of lesions typical of cerebral microangiopathy and a trend to multiple infarctions in the former.Impairment of cognitive processing as measured by visual event-related potential is more pronounced in hyperhymocysteinemia. |
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